GWAS-related eQTLs across different cancer types
We identified 337,131 eQTLs that overlap with GWAS linkage disequilibrium (LD) regions (r² ≥ 0.5).
|
Cancer type
|
eQTL type
|
tagSNP
|
Gene position (hg19)
|
p-value
|
|||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| BLCA | cis | rs6715284 | 1 | rs16837131 | chr2:202173812 | PPIL3 | chr2:201735680-201753999:- | 0.42 | 4.62 | 5.25E-6 | Rheumatoid arthritis |
| BLCA | cis | rs16870629 | 1 | rs16870629 | chr5:1015063 | CLPTM1L | chr5:1318007-1345002:- | -0.23 | -4.19 | 3.47E-5 | QT interval |
| BLCA | cis | rs1577917 | 1 | rs16876529 | chr6:86591202 | SNHG5 | chr6:86386726-86388451:- | -0.6 | -10.81 | 5.77E-24 | Response to antipsychotic treatment |
| BLCA | cis | rs335810 | 1 | rs16942155 | chr15:60418758 | GTF2A2 | chr15:59930263-59949737:- | 0.41 | 3.88 | 0.000122 | Type 2 diabetes |
| BLCA | cis | rs732528 | 1 | rs16952611 | chr18:48382668 | MRO | chr18:48321491-48351754:- | -0.23 | -4.24 | 2.77E-5 | Entorhinal cortical thickness |
| BLCA | cis | rs16974263 | 1 | rs16974263 | chr19:40913539 | ZNF546 | chr19:40502943-40523514:+ | 0.25 | 4.16 | 4.01E-5 | Otitis media (recurrent);Otitis media (chronic);Otitis media |
| BLCA | cis | rs7655841 | 1 | rs1699379 | chr4:129992337 | C4orf33 | chr4:130014829-130033842:+ | -0.33 | -5.43 | 1.02E-7 | Chronic obstructive pulmonary disease (moderate to severe) |
| BLCA | cis | rs7655841 | 1 | rs1699389 | chr4:130004079 | C4orf33 | chr4:130014829-130033842:+ | -0.34 | -5.6 | 4.12E-8 | Chronic obstructive pulmonary disease (moderate to severe) |
| BLCA | cis | rs7655841 | 1 | rs1699391 | chr4:130005096 | C4orf33 | chr4:130014829-130033842:+ | -0.34 | -5.6 | 4.12E-8 | Chronic obstructive pulmonary disease (moderate to severe) |
| BLCA | cis | rs7655841 | 1 | rs1699392 | chr4:130022347 | C4orf33 | chr4:130014829-130033842:+ | -0.33 | -5.42 | 1.04E-7 | Chronic obstructive pulmonary disease (moderate to severe) |
| BLCA | cis | rs7655841 | 1 | rs1699393 | chr4:130019352 | C4orf33 | chr4:130014829-130033842:+ | -0.33 | -5.44 | 9.44E-8 | Chronic obstructive pulmonary disease (moderate to severe) |
| BLCA | cis | rs7655841 | 1 | rs1699394 | chr4:130019312 | C4orf33 | chr4:130014829-130033842:+ | -0.34 | -5.66 | 3.01E-8 | Chronic obstructive pulmonary disease (moderate to severe) |
| BLCA | cis | rs2243480 | 1 | rs1701750 | chr7:65467145 | CCT6P1 | chr7:65216092-65228661:+ | 0.3 | 4.29 | 2.25E-5 | Diabetic kidney disease |
| BLCA | cis | rs2243480 | 1 | rs1701758 | chr7:65470201 | CCT6P1 | chr7:65216092-65228661:+ | 0.3 | 4.28 | 2.37E-5 | Diabetic kidney disease |
| BLCA | cis | rs17030613 | 1 | rs17030613 | chr1:113190807 | ST7L | chr1:113066142-113162405:- | 0.41 | 6.02 | 4.16E-9 | Diastolic blood pressure;Blood pressure |